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Cholesterol accumulation can also impair the function of innate immune system cells, such as natural killer (NK) cellscytotoxic lymphocytes of the innate immune system that recognize and eliminate stressed, transformed, or infected cells without prior sensitizationby reducing their cytotoxic capacity and increasing the risk of HCC in the context of MASLD [35, 36]

In high fat and high sugar model of NAFLD, cassia glycosides can obviously improve liver function and regulate blood lipids when compared with the commonly used drug polyene phosphatidylcholine in clinic, which is related with the inhibition of SREBP-1c expression in liver [112]