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That 28-day window reflects the limit of copper-peptide complex stability in aqueous solution at refrigeration temperature

When iron and copper ions are released from proteins, they can contribute to the generation of OH, with certain chelators acting as enhancers and others functioning as inhibitors [228]

Studies have shown that hydroxytyrosol is considered a highly effective antioxidant and free radical scavenger with an ORAC value (oxygen radical absorbance capacity) of 45,000 molTE1 per gram, 30 times higher than many well-known antioxidants

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For research institutions designing protocols, this context is essential: the compounds therapeutic potential is supported by a large body of animal research, but translation to human outcomes remains an active area of investigation rather than established clinical fact