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27,28,29 But it was not until the discovery of signaling mediators small (Sma) in Caenorhabditis elegans and mothers against decapentaplegic (Mad) in Drosophila melanogaster that the homologous small mothers against decapentaplegic (SMAD) proteins were identified as the canonical signal transducers of TGF- signaling in humans in 1996

Abstract Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to produce the levels of ATP required to perform physiological functions exceeds the vascular supply, thereby leading to a state of oxygen depletion with the associated risk of bioenergetic crisis

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Stroke Ischemic stroke is uncommon in women before menopause and increases substantially as women age, leading to the premise that women are protected early in life by reproductive hormones (Barrett-Connor and Bush, 1991

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Scientific Classification A synthetic 29-amino-acid class B1 peptide-receptor ligand