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Finally, immune-related adverse effects and long-term safety profiles have not been comprehensively assessed, potentially limiting the broader clinical application of TBX21 -targeted therapies in immune-mediated diseases and cancer

doi:10.1016/j.maturitas.2019.02.011 Zhang L, Ou X, Zhu T, Lv X

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These studies involved small numbers, short observation periods or limited safety reporting

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Abstract Glutamate excitotoxicity is intricately linked to the pathogenesis of neurodegenerative diseases, exerting a profound influence on cognitive functions such as learning and memory in mammals