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If yes, your skin may simply need longer adjustment

ClinicalTrials.gov lists 3 ongoing or completed trials (accessed February 12, 2026): NCT05239615 (topical for photoaging, Phase II, completed 2024, no results posted) [12]

Stability concerns mean that some percentage of the copper peptide oxidizes before reaching its target

They work through different mechanisms

It reduces total peptide usage by about 15% and provides weekly micro-washouts that protect receptor sensitivity during longer cycles

Accumulation over time: Even small amounts crossing barrier may accumulate with repeated dosing producing therapeutic concentrations