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Administration of NaB enhanced the acetylation level especially H4 histone in the mouse hippocampus and cerebral cortex, accompanied with the elevation of IEGs (c-fos and Arc) and neurotrophins (BDNF and NT-4) [147]

Beclin-1 haplo-insufficiency worsens inflammasome activation, cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) signalling, cytokine output, and motor decline, whereas trehalose restores flux, dampens these responses, and improves recovery ( via TNF-, NO, and glutamate, killing oligodendrocytes and activating astrocytes to produce proteoglycan-rich scars

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Figure 3 summarises the contribution of glycolysis and related molecules/signaling pathways to IS

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doi: 10.34172/bi.30071 19