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An HF containing 20 monomers, comprising two hexamers spaced by an octamer (likely in a favorable conformation, such as helicoidal), each binding to a CD44 receptor, achieves optimal efficacy [33]

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This suggests an extremely wide safety margin, at least in animal models

Artificial disc prosthesis for the treatment of degenerative intervertebral disc mainly aims at restoring the mechanical properties of the IVD (such as the height of intervertebral space and local mobility of spine) and also raises requirements for biological properties (such as promoting the growth and differentiation of IVD cells)

doi: 10.3390/cells10010027 13 BergmanM

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