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4.2.2 NAM-competitive inhibitors NAM-competitive inhibitors are substances that can compete with the substrate NAM for the binding site in NNMT

Some people have persistent depression

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Studies have found that more than 80% of HAPH patients have bone morphogenetic protein receptor II (BMPR2) mutations

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Finally, the extension to overweight and metabolically compromised populations is made at conceptual level in this section, with limited narrative detail, which constrains the ability to appraise risk of bias or effect robustness and therefore makes the supporting evidence weak but directionally consistent with the other trials