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The deficiency symptoms include weakness, numbness, tingling, dizziness, memory loss, depression, balance problems, confusion, dementia, fatigue, palpitations, tachycardia, shortness of breath, nausea, lack of appetite, weight loss, diarrhea, constipation, soreness and redness in tongue with loss of papillae, difficulty walking, muscle weakness, irritability, and/or vision loss

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Additionally, they established that according to the WHO definition for MetS, each unit increase in log-transformed IGF-1 concentrations, was associated with a 90.5 % reduction in the risk of MetS [226]

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The subjects were given AOD9604 of 500 microg/kg body weight or placebo for 19 days