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Atrazine, a non-competitive inhibitor of the DNMT reaction, significantly reduces DNMT1 activity

10.1002/glia.23105 Glia 147 NiuX.StancliffeE.GelmanS

Keating, MKantarjian H, Gandhi V, OBrien S, Koller C, Kornblau S, Beran M, Andreeff M , Plunkett W, Freireich E

Chelation therapy removes harmful metals from the body

350 Mitochondrial dysfunction in Schwann cells triggers alterations in lipid metabolism, leading to myelin sheath dysfunction and accumulation of toxic lipid intermediates, which cause axonal degeneration and neuropathy

Our model is complementary to the work of [10] since it focuses on the detailed biochemical mechanisms by which of APAP is detoxified in the liver under both normal and overdose situations