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Xanthine oxidoreductase is transformed by proteases into xanthine oxidase, which is then able to transfer electrons from xanthine to oxygen to generate ROS and participate in the inflammatory pathway by inactivating MAPK phosphatase-1, leading to JNK phosphorylation in macrophages (Nomura et al., 2013)

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Engineered to reduce IGFBP binding extends plasma half-life from ~10 min (native) to ~6 hr (LR3)

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The peptide is one of the more popular ones on the internet, and there are a wide array of companies that sell it