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S4), indicating its role in iron inter-tissue trafficking

At the molecular/physiological level, the naked mole-rat shows typical age-related decline, e.g., in activity levels, skin structure (Buffenstein and Jarvis, 2002), liver detoxification pathways (Heinze et al., 2018), lesion and lipofuscin accumulation in various organs (Edrey et al., 2011)

Co-localization with RNA-polymerase II and binding to chromatin, as shown by co-precipitation with histone H3, further support a transcriptional regulation role for IGF-1R [88,89]

Clinical and animal studies have confirmed that the tumor necrosis factor- (TNF-) inhibitor pentoxifylline treats AH and exerts anti-inflammatory effects by inhibiting phosphodiesterase

Since the primary source of ROS is mitochondria, mitochondrial dysfunction should be the initial step in an explosive increase in ROS

Hepatic mitochondria provide a hub for liver metabolic homeostasis by uniquely integrating or coordinating multiple metabolic pathways of carbohydrate, lipid, cholesterol, bile acid, and amino acids for energy homeostasis and by keeping the balance of reducing equivalents and intermediary metabolites in the liver and whole body via mitochondria-cytoplasm shuttles