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In an interesting crosstalk between Akt and the NAD-dependent deacetylase family of Sirtuins, Sirt1 also modulates the transcriptional activity of FoxO1 (Zhao et al., 2010), and this cytoplasmic, transcription-independent function of FoxO1 requires its deacetylation by Sirt2, and is facilitated by nuclear exclusion of FoxO1 by Akt-dependent phosphorylation (Zhou et al., 2012)

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Its dual role in both innate and adaptive immunity , along with its favourable pharmacological properties, makes it a valuable tool in modern peptide science