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Ketones are well-suited for these metabolic shifts as sensory neurons effectively use them to produce acetyl-CoA and enter the TCA cycle to produce electron transport chain electron donors[21]

26,68,69 At least two mechanisms have been proposed to explain the deficient IFN-I response: (1) previous studies have suggested that SARS-CoV employs various mechanisms to inhibit IFN response, especially through the components of its structural proteins such as M protein, 70 N protein, 71 open-reading frame 3a (ORF3a) protein, 72 and ORF6 protein

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The challenge is that glutathione is poorly absorbed when taken orally