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Oral administration is generally ineffective due to gastric peptidase degradation, and intravenous (IV) routes are rarely used outside pharmacokinetic studies due to rapid clearance and the need for continuous infusion to maintain therapeutic levels

& Rabinovici, G

Germann '70 Paul F

Targeted ablation of p16 + senescent cells or treatment with Senolytics resulted in the disruption of collagen structure and the retardation of epidermal coverage