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The inconsistency in diagnostic standards and case definitions for ME/CFS poses a major obstacle to its clinical diagnosis

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pylori , which is associated with gastritis and increased cancer risk, secretes VacA toxin, a virulence factor that upregulates VEGF expression in the epithelial cells of the gut, activating the epithelial growth factor receptor (EGFR), mitogen-activated protein kinase (MAPK), and COX-2 pathways (150)

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Sleep apnea, and particularly obstructive sleep apnea, is highly prevalent in patients with cardiovascular disease (CVD), including heart failure, stroke, atrial fibrillation, and end-stage renal disease