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The sudden death of Shefali at just 42 has left many shocked and concerned, with early reports linking her cardiac arrest to an IV glutathione drip taken while fasting

Accumulation of A aggregates and longer As in Rab7-positive late endosomes and cathepsin D-positive autophagolysosome and mitochondria suggest that age-related changes in iA processing limit completion of autophagic and endocytic processes in aged neurons [1]

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This represents the first comprehensive systemic analysis of lactylation modifications in the brain, providing a solid foundation for further exploration into the role of lactylation in the spectrum of psychiatric disorders