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OxLDL also plays a pro-inflammatory role by stimulating endothelial cells to express adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) [71]

Drug-related resistance mechanisms include increased drug efflux via ABC transporters, decreased drug absorption caused by changes in lipid metabolism or drug carrier family member expression, and altered drug targeting

The ultimate effect of p53 is highly dependent on the cell type and the specific stress context (41)

However, the immune response of the CNS is complex and involves a myriad of diverse cell populations such as astrocytes, microglia, macrophages, NK cells, and T and B cells (Aoyama, 2021)

Targeting antioxidant pathways in combination with metabolic or oxidative therapies may overcome resistance [79]

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