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Increased oxidative stress and energy depletion contribute to cellular dysfunction and apoptosis, highlighting the need for antioxidant therapies

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EPOR mutations result in truncated forms of the EPO receptor, which in turn causes EPO hypersensitivity in erythroid progenitors

Detoxification : Glutathione plays a vital role in the detoxification of harmful substances and heavy metals, making it essential for liver health

Berberine, a bioactive alkaloid derived from traditional Chinese herbal medicines, demonstrates the capacity to suppress TMAO production through modulation of the gut microbiomes microbial composition

This signaling pathway is critically involved in the regulation of cell growth, (anti-)apoptosis, translation, but also the basic carbon metabolism (Courtnay et al., 2015) (Figure 2)