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Endothelial dysfunction has been demonstrated in vivo (306, 311), in the large vessels of ME/CFS patients (307, 311) through flow-mediated dilation (FMD) and in the microcirculation through post-occlusive reactive hyperaemia

From that program, two distinct peptides emerged the linear MC1R-preferential analog that became afamelanotide, and the cyclic broad-spectrum analog that became Melanotan 2

Recent reports from Europe suggest good early effectiveness against severe disease, including subclade K

Differentially expressed genes are significantly enriched in redox processes (GO:0055114) and oxidoreductase activity (GO:0051903, GO:0004022, GO:0050607), highly consistent with the aforementioned biochemical phenotypes

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Quiles MT, Arbs MA, Fraga A, de Torres IM, Revents J, Morote J