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MECHANISM CATEGORIES SAFETY Side effects Generally well-tolerated in trials at the doses tested Injection-site reactions Known interactions Not characterized in Phase 3 Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved as a drug

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Improvement was noted at each of four evaluations, and lasting improvement was attributed to the biofeedback portion of treatment program

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A randomized clinical study involving 75 women found that sublingual epitalon at 0.5 mg per day for 20 days produced measurable increases in melatonin synthesis

Instead of making good antibodies, they make bad proteins