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In a nitroglycerin-induced migraine model in rats, we have observed similar iron accumulation in serum (unpublished data)

Molecules 24 (17), 3154

doi: 10.1016/j.ejphar.2024.176399 40 HanJJLiXYeZQLuXYYangTTianJet al

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It should be noted that the relatively higher uptake rates of aspartate and glutamate or glutamine (Supplemental data 1) are to satisfy the additional demands imposed by peptidoglycan biosynthetic precursors, D-alanine and glucosamine-6-phosphate

The bloodbrain barrier (BBB) endothelial cells also play a critical role: they regulate the bidirectional transport of pathological proteins like -synuclein, and their dysfunction impairs protein clearance while promoting aggregation, thereby accelerating PD pathology