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Certain anaerobic gut bacteria express ET hydrolases that cleave ET into trimethylamine (TMA), which the liver converts into trimethylamine-N-oxide (TMAO)a notorious pro-atherogenic metabolite linked to accelerated vascular aging and cardiovascular disease

Common side effects, serious warnings, and contraindications vary by compound

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Microbiota-based therapies, such as probiotics and FMT, are being explored as adjunct treatments for MASLD, primarily due to the gut-liver axis's role in disease progression

37 DixitK.ChaudhariD.DhotreD.ShoucheY.SarojS