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It upregulates genes involved in repair, antioxidant defense, and stem cell function while downregulating genes associated with inflammation, fibrosis, and tissue destruction

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It is likely that the most well-known function of NADPH oxidase-derived superoxide is the inactivation of NO in the reaction that forms peroxynitrite, which leads to impaired endothelium dependent vasodilation and the uncoupling of endothelial NO synthase (eNOS) to produce additional superoxide