Glutamine catabolism, which starts with the hydrolysis of glutamine to glutamate, catalyzed by the glutaminase family of enzymes, becomes highly upregulated in cancer cells to compensate for the uncoupling of the glycolytic pathway from the TCA cycle due to the Warburg effect, thus providing the biosynthetic precursors necessary for their enhanced proliferation and survival [7-10]
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Therefore, one can speculate that a larger concentration of glutamate provides a higher efficiency at relaying the metabolic activation of glycolysis during neuronal stimulation with the respiratory rate of mitochondria
Nano-enabled photosynthesis in tumours to activate lipid peroxidation for overcoming cancer resistances
Modern microplate readers play an important role as they enable the analysis of different metabolic parameters in higher throughput and in an automated manner
