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Conversely, the mRNA and protein levels of SREBP2 precursor increased, while the mature form of SREBP2 decreased (Fig

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This so-called autocrine loop of ROS by HSCs is regarded as mechanism corresponding to the autocrine loop of TGF- which HSCs produce in response to this cytokine with an increased collagen expression in the injured liver (Itagaki et al., 2005)

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Two studies on athletes showed that exogenous administration of melatonin can alleviate oxidative stress, inflammation, and muscle damage, and might improve exercise performance 60,61