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Lipid droplet-associated mitochondria exhibit increased fatty acid oxidation, as indicated by elevated levels of phosphorylated ACC2 (pACC2), Mitofusin 2 protein (MFN2) and CPT1 activity, but are damaged by fatty acid oxidation in an NAFLD rat model [56]

[150] In simpler terms, this necessary and sufficient relationship means that FosB overexpression in the nucleus accumbens and addiction-related behavioral and neural adaptations always occur together and never occur alone