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Patients should be advised to report to the physician immediately any of the following: numbness or tingling in the fingers and toes, muscle pain in the arms and legs, weakness in the legs, pain in the chest, temporary speeding or slowing of the heart rate, swelling, or itching

Copper and zinc are cofactors for the endogenous antioxidant enzyme called superoxide dismutase

doi: 10.1046/j.1365-2567.2002.01490.x 76 Costa JdeOFonsecaKCMamedeCCBelettiMESantos-FilhoNASoaresAMet al

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