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Furthermore, GSH production is directly regulated by GPX4 22

Cadmium (Cd) is a common heavy metal contaminant that has been demonstrated to cause organ damage through the activation of inflammatory processes, oxidative stress, mitochondrial damage, and cell death, which ultimately leads to neurotoxicity, gastrointestinal damage, renal damage, and reproductive damage [124, 125]

The animals fed a selenium-deficient diet recapitulated some of the pathological manifestations of KBD, strongly supporting the notion that selenium deficiency is critically associated with the development of this endemic arthropathy

Zinc plays a vital role in maintaining the homeostasis of intestinal epithelial cells, and its deficiency can lead to alterations in their integrity and function

Therapeutic strategies targeting oxidative stress in cancer are being explored, given the critical role of free radicals in tumor biology

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