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The mitogen-activated protein kinase signaling module as a therapeutic target in hematologic malignancies

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Blood 124 , 38293830 (2014)

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Previous studies have shown that DSF inhibits key components of the PI3K-Akt pathway and reduces cell survival and proliferation, thereby exerting anti-tumor and antifibrotic effects

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Serine deprivation activates the serine synthesis pathway and reroutes carbon flux from glycolysis to the TCA cycle

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