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& Menezes, J

doi: 10.1093/bioinformatics/bty149 6 DeshayesC.BieleckaM

Several compounds have been identified as NAPRT inhibitors, e.g., 2-hydroxinicotinic acid (2-HNA) 216 which has been shown to be able to enhance the inhibitory effect of FK866

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Furthermore, glycocalyx degradation impairs its ability to bind key anticoagulant proteins, such as activated protein C (aPC), tissue factor pathway inhibitor (TFPI), and antithrombin III, thereby shifting the hemostatic balance toward a procoagulant state