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Figure 2 Immediately following a bee sting, the venom delivery system remains embedded in the skin for approximately 30 seconds, allowing for venom release, with at least 90% injected within the first 20 seconds ( 50 ) is 2.8-3.5 mg/kg of body weight ( Typically, the clinical manifestations of bee envenomation can be categorized into local inflammatory reactions, allergic reactions, anaphylactic shock, and systemic toxic reactions ( 3 Bee venom: molecular basis of physiopathology A typical bee sting elicits a local inflammatory response characterized by pain, edema, and erythema

In neutrophils, NADPHox-derived ROS upregulate NF-B activity and B-cell lymphoma-extra large [Bcl-X (L)] accumulation and inhibit Bax insertion into the mitochondria, thus resulting in pro-inflammatory and anti-apoptotic responses to neutrophils (Moraes et al., 2012)

Dimmeler S, Ding S, Rando TA, Trounson A (2014) Translational strategies and challenges in regenerative medicine

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Deficiencies in cystathionase activity have also been shown to contribute to glutathione depletion in patients with cancer and AIDS

Xie D, Wang P, Chen W, Lin J, Wu M, Wang Y, et al