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for developing a novel murine closed-skull traumatic brain injury (TBI) model and using it to demonstrate that the mouse skull, whether thinned or intact, is permeable to drugs, allowing "transcranial" drug delivery into the underlying cerebral cortex with consequent reduction in injury-related cell death when glutathione is delivered

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Among these genes, 1424 were upregulated and 1,561 were down-regulated (Xie et al., 2015)

Pickarts initial observation was that human albumin fractions containing GHK could regenerate aged liver tissue in culture a finding that launched the broader investigation into GHK Cus biological activity

Due to their diminutive size, NPs possess not only the capability to traverse cell membranes or the bloodbrain barrier for targeted drug delivery but also evade immune surveillance to prolong their retention times within biological tissues

Notably, the overexpression of Glr1 emerged as the most efficacious, amplifying glucoamylase enzyme activity by 243% and total protein secretion by 88%