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OKeeffeSAmedeTBocklineBKajobeRReemerTHaggardBet al

Regarding the use of MMRi for brain tumors, further studies are needed to evaluate its efficacy in crossing the BBB and the specificity of targeting cancer cells, as well as to assess off-target neurotoxicity

10.1016/j.jaad.2017.09.012 32 LaimerM.KocherT.ChiocchettiA.TrostA.LottspeichF.RichterK.et al (2010)

Combine BsAbs with TMZ/radiotherapy to upregulate targets (e.g., NKG2D ligands) and DAMPs, enhance immune infiltration, and exploit transient radiotherapy-induced BBB permeability to improve penetration

North, 2016

Besides that, purine and pyrimidine synthesis use also glutamine-derived aspartate, whose supplementation can rescue cell cycle arrest caused by glutamine deprivation [44]