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Regarding the triple combination, the pathways are highly similar to those of (M+D)/2, with an additional enrichment in pathways associated with anion transmembrane transporter activity ( Figure 7B )

In the FDA report published in December, the most common side effects were pain at injection site (91.6% of patients), fatigue (68.5%), headache (63.0%), muscle pain (59.6%), joint pain (44.8%), and chills (43.4%)

Some may experience numbness or tingling in their hands and feet due to nerve damage caused by low B12 levels

however, the primary reason for this choice is tolerability rather than proven superior absorption

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the placebo group (1)