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The terminal carboxylic groups of PLGA chains impart its surface negatively charged, which can be modified through functionalization to facilitate targeted drug delivery 110

Nat Neurosci 12:393395 Durieux PF, Schiffmann SN, de Kerchove dExaerde A (2012) Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions