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The principal mechanisms underlying this modulation include regulation of hydrolytic enzyme activity, generation of ROS during phagocytosis, chemokine-driven recruitment, formation of neutrophil extracellular traps (NETs), and control of inflammatory cytokine secretion

This includes screening lipid-to-peptide ratios, selecting edge activators for "transfersome" capability, and tuning cholesterol levels to adjust membrane rigidity, preventing leakage of the small peptide molecules

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(2) Ligand preparation: The SDF structure files of the small molecules were downloaded, and hydrogen atoms were added, followed by energy minimization