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Third, PA calcification has been linked to hypoxia, in that hypoxia decreases the expression of serine protease granzyme B stored in the granules of T lymphocytes and natural killer cells, which inhibits store-operated calcium channels (SOCCs) as the main source of calcium mineral by attenuating non-canonical Wnt signals in SMCs, thus increasing calcification of the PA (141)

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(2018) sought to determine the effect of riluzole by measuring the impact of riluzole on presynaptic activity, synaptic vesicle recycling and glutamate release

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The cleanest experiment is to discontinue and see if the symptom resolves

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