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This excessive ROS accumulation leads to oxidative stress, which disrupts metabolic pathways, ultimately contributing to wrinkles and other symptoms of aging (Mai et al., 2019)

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Additionally, when vitamin C is incubated with peripheral blood lymphocytes in vitro, it reduces the production of various inflammatory cytokines, such as TNF- and IFN-, induced by lipopolysaccharide, whilst increasing the production of the anti-inflammatory cytokine IL-10 (50)

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Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structureactivity relationships, lead optimization, and chronic in vivo efficacy