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Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology

The reaction of NO with O 2 leads to formation of peroxynitrite (ONOO )

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doi: 10.1016/j.phrs.2021.105742 79 RathSDasLKokateSBPratheekBMChattopadhyaySGoswamiCet al

Cancer Cell Int (2018) 18:7

This review provides a comprehensive overview of ROS production in PCa, the interplay between androgens and ROS, the role of external factors such as obesity and aging in promoting ROS generation, and how elevated ROS levels alter the PCa microenvironment, promoting inflammation, activating the unfolded protein response (UPR), and regulating miRNA expression, all of which contribute to the progression of PCa