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Injection of FOXO4-DRI in both naturally aged and induced-aging mice suppressed aortic aging and improved aortic function while alleviating endothelial cell senescence (PMID: 41625068)

NeuroImage 86 , 1018 (2014)

Both peptides show published activity across rodent and cell-culture tissue-repair models without binding a single canonical receptor, distinguishing the blend from receptor-targeted compounds

Despite these promising findings, current evidence is preliminary, and the mechanistic basis for any comparative or synergistic advantages remains speculative

The term thiamine-responsive refers to the observation of clinical, symptomatic improvement after administration of high doses of thiamine (86, 87)

However, selenium and zinc levels are not reliably found via blood tests