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Description

Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models

Int J Mol Med (2020) 45(4):120312

Cth f/f mice were fed CTRL or CysF diet for 6 days

FAA, which accumulates in FAH deficiency, is highly electrophilic and a potent alkylator, causing oxidative damage to the cells in which it is generated by reacting with glutathione and sulfhydryl groups of proteins