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Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade

The primary outcome was a composite endpoint of all-cause mortality, decompensation of cirrhosis (ascites, variceal haemorrhage, hepatic encephalopathy), hepatocellular carcinoma, liver transplantation or progression to a model of end stage liver disease score 15

Recent research (Li et al., 2022a) has revealed that TCM is efficacious in treating AMD by modulating the GM, offering a novel approach to preventing and managing AMD

The concomitant modulation of Nrf2 suggests that a functional AGE/RAGE-Nrf2 axis contributes to this protective effect

The effect is dose dependent

There was also an improvement in the ratio of GSSG to GSH, with the largest decrease in this ratio among those taking the higher dose in the first and second weeks