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In extreme cases, thiamine deficiency can cause neuronal death due to lack of cellular energy from impaired ATP production

10.1016/j.tcm.2021.10.006 103 SunJ.TongY.JiaY.JiaX.WangH.ChenY.et al

qtot 0.266 9 OG311 1 ful O9 9 -0.554 15.9994

The targeted delivery of intracellular copper relies on multiple metallochaperone systems:(a) Cytochrome c oxidase copper chaperone COX17 (Cox17) transports copper to mitochondria and participates in cytochrome c oxidase assembly (Amaravadi et al., 1997)