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It also reduces the intramitochondrial ratio of acetyl-CoA to free CoA, which in turn stimulates pyruvate dehydrogenase activity and promotes pyruvate oxidation

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Recipient liver disease etiology included alcoholic liver disease (n=189 [31.3%]), Hepatitis C (n=181 [30.0%]), NASH/NAFLD (n=102 [16.9%]), autoimmune liver disease (n=32 [5.3%]), and all other (n=42 [7.0%])

171,190 Currently, numerous drugs targeting inflammation-related receptors, signaling pathways, and pro-inflammatory cytokines are under clinical trials

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