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161 In gut microbiota analysis of early-stage liver fibrosis (F0F2), 50% of disease-associated taxa are Enterobacteriaceae, Pseudomonadaceae, Flavobacteriaceae, and Burkholderiaceae, among which Flavobacteriaceae and Xanthomonadaceae can distinguish F0 from F1 stages

Based on animal models, it appears that TNF and interferon- act synergistically to promote cell death and inhibit hepatocyte regeneration [64]

Vertical reference lines correspond to CV values of 0.2 and 0.3, and the horizontal reference line represents 80% of the total number of substances

Also sulfate homeostasis will be disturbed in order to constantly maintain the GSH content

At this stage, the hematological defects are indistinguishable from those of folate deficiency and include megaloblastic anemia, characterized by macro-ovalocytic erythrocytes, abnormal red cell indices, and a low hemoglobin concentration (see Chapter 17, Sections 17.2.7 and 17.4)

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