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(ii) The improvement in anxiety and depression could have been partially related to the improvement in physical symptoms in most patients, especially in the three patients only treated with topical O 3 administration

Lactate-driven lactylation at lysines 218 and 228 (K218/K228) of GPX4 significantly reduces its protein stability, impairing its ability to clear lipid peroxides and enhancing ferroptosis sensitivity (69,70)

BJ: Conceptualization, Writing review & editing

3, comparable to the R495X mutation)

These findings indicate that MSG may trigger oxidative stress by suppressing the expression and activity of thioredoxin reductase, an important antioxidant enzyme in the liver

A survey in BD I/II patients under lithium treatment (16 weeks) utilized CellPrint flow cytometry to quantify levels of multiple intracellular proteins in CD4 + lymphocytes and monocytes, comparing responders and non-responders in monotherapy for BD I or II to explore potential predictive biomarkers of therapeutic response