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Protein-bound uremic toxins impaired mitochondrial dynamics and functions

8.1 Mitochondrial complex I and epilepsy Mitochondrial complex I, also known as NADH dehydrogenase or NADH-Q reductase, consists of 45 structural subunits

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This oligomerization leads to protein toxic stress, ultimately inducing cell death

Neuroimaging and postmortem studies have suggested that pathological changes in the anterior cingulate cortex, hippocampus, prefrontal cortex, and amygdala are linked to NPS, although the precise mechanisms remain unclear

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