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In metabolic disorders, such as metabolic dysfunction-associated steatotic liver disease (MASLD), ferroptosis exacerbates lipid oxidation and contributes to tissue damage [91]

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NNMT inhibition as a therapeutic strategy has been explored in industry pharmaceutical pipelines (including a Pfizer program for non-alcoholic fatty liver disease that was reportedly discontinued in early clinical development), but no NNMT inhibitor has reached regulatory approval to date

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Half-life Circulating GSH half-life is short reported in the range of minutes in plasma due to rapid uptake by tissues and catabolic turnover via -glutamyl transpeptidase

PMID 13642195