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Tang X, et al

Mitochondrial GSH sequesters copper, preventing its binding to lipoylated proteins, such as DLAT, thereby blocking the aberrant protein oligomerization that drives this cell death pathway [109]

& Bailey, J

Anti-Aging Therapeutics

and (ii) off-target resistance caused by the activation of bypass signal transduction resulting from the amplification of the ERBB family of receptor tyrosine kinase genes, BRAF amplification, KRAS amplification, and KRAS mutations [148]

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